Cell survival is dicey without Dicer
نویسندگان
چکیده
The cellular requirements of Dicer, an essential miRNA processing enzyme, and the consequences of altered levels of it on tumorigenesis are incompletely understood. We review the effects of Dicer loss in cells of different origin and whether loss of p53 permits cell survival and growth in the absence of Dicer.
منابع مشابه
Inactivation of p53 is insufficient to allow B cells and B-cell lymphomas to survive without Dicer.
Inactivation of p53, the master regulator of cellular stress and damage signals, often allows cells that should die or senesce to live. Loss of Dicer, an RNase III-like enzyme critical in microRNA biogenesis, causes embryonic lethality and activation of the p53 pathway. Several nonhematopoietic cell types that contain inactivated p53 have been shown to survive Dicer deletion, suggesting that p5...
متن کاملTumor and Stem Cell Biology Inactivation of p53 Is Insufficient to Allow B Cells and B-Cell Lymphomas to Survive Without Dicer
Inactivation of p53, themaster regulator of cellular stress and damage signals, often allows cells that should die or senesce to live. Loss of Dicer, an RNase III–like enzyme critical in microRNA biogenesis, causes embryonic lethality and activation of the p53 pathway. Several nonhematopoietic cell types that contain inactivated p53 have been shown to surviveDicerdeletion, suggesting that p53 l...
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